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Commercial Real Estate for Sale and Lease in Seneca, SC | Realty.com
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Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

Make the deal

  • Writing a winning offer
  • Inspections & appraisals
  • Closing costs, itemized
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Safety & registry resources

Review official public-safety information for any area from these government sources:

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Save search
Sell

Selling Options

  • What's my home worth?
  • Compare selling options
  • Get an instant cash offer
  • Buy before you sell

Resources

  • How selling works
  • When should I sell?
  • Home selling tips
  • Pricing your home
  • What's worth fixing first
  • Find a seller's agent
Home Loans
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27 listings

Commercial Real Estate for Sale and Lease in Seneca, SC

Commercial Real Estate for Sale and Lease in Seneca, SC

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24 of 27 Listings
Map

Commercial Real Estate for Sale and Lease in Seneca, SC

24 of 27 Listings

  1. 1510 Blue Ridge Boulevard 103 — photo29Active

    $399,999

    — bd · 0 ba · — sqft

    1510 Blue Ridge Boulevard 103, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  2. 1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd — photoPrice Reduced20Active

    $895,000

    — bd · 0 ba · — sqft

    1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  3. Tract 18/19 S Walnut Street — photo20Active

    $265,000

    — bd · 0 ba · — sqft

    Tract 18/19 S Walnut Street, Seneca, SC

    Janet Cartee · Western Upstate Keller William

  4. 205 Stork Way Upper Unit — photo18Active

    $1,300/mo

    — bd · 0 ba · — sqft

    205 Stork Way Upper Unit, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  5. 528 By Pass 123 Highway C — photo21Active

    $375,000

    — bd · 0 ba · — sqft

    528 By Pass 123 Highway C, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  6. listing photo21Active

    $375,000

    — bd · 1 ba · 1,289 sqft

    Address withheld · Seneca, SC

    Adrienne F Hennes · RE/MAX EXECUTIVE

  7. 10695 Clemson Boulevard — photo40Active

    $789,000

    — bd · 0 ba · — sqft

    10695 Clemson Boulevard, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  8. 528 By Pass 123 Highway Suite B — photoPrice Reduced17Active

    $325,000

    — bd · 0 ba · — sqft

    528 By Pass 123 Highway Suite B, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  9. 518 W North 1st Street — photoPrice Reduced32Active

    $1,695,000

    — bd · 0 ba · — sqft

    518 W North 1st Street, Seneca, SC

    Tommy Stevenson · Western Upstate Keller William

  10. 195 Meade Street — photo11Active

    $750,000

    — bd · 0 ba · — sqft

    195 Meade Street, Seneca, SC

    Amanda Herring · Keller Williams Seneca

  11. 879 By Pass 123 Highway Includes 710 Seneca Drive — photo18Active

    $4,000/mo

    — bd · 0 ba · — sqft

    879 By Pass 123 Highway Includes 710 Seneca Drive, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  12. 879 By Pass 123 Highway Includes 710 Seneca Drive — photo18Active

    $677,000/mo

    — bd · 0 ba · — sqft

    879 By Pass 123 Highway Includes 710 Seneca Drive, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  13. 306 Highway 123 ByPass Building B — photoPrice Reduced32Active

    $2,500/mo

    — bd · 0 ba · — sqft

    306 Highway 123 ByPass Building B, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  14. 0 Corner of Wells Hwy. & Return Church Rd. Highway — photo18Active

    $395,000

    — bd · 0 ba · — sqft

    0 Corner of Wells Hwy. & Return Church Rd. Highway, Seneca, SC

    Tucker Hydrick · Keller Williams Seneca

  15. 124 and 118 N Townville Street Ye Ole Restaurant — photoPrice Reduced25Active

    $799,000

    — bd · 0 ba · — sqft

    124 and 118 N Townville Street Ye Ole Restaurant, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  16. 110 E N 1st Street — photoPrice Reduced6Active

    $429,943

    — bd · 0 ba · — sqft

    110 E N 1st Street, Seneca, SC

    Andrew Campbell · Real Local/Real Broker, LLC

  17. 10149 and 10161 Clemson Boulevard — photoPrice Reduced9Active

    $1,400,000

    — bd · 0 ba · — sqft

    10149 and 10161 Clemson Boulevard, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  18. 1510 Blue Ridge Boulevard 202 — photoPrice Reduced47Active

    $3,000/mo

    — bd · 0 ba · — sqft

    1510 Blue Ridge Boulevard 202, Seneca, SC

    David Land · BuyKeowee Real Estate

  19. 99 Northampton Road w/Hill Top Drive Acreage — photo15Active

    $2,100,000

    — bd · 0 ba · — sqft

    99 Northampton Road w/Hill Top Drive Acreage, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  20. 1018 E. North 1st Street — photo20Active

    $3,500,000

    — bd · 0 ba · — sqft

    1018 E. North 1st Street, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  21. 11081 N Radio Station Road — photo10Active

    $217,000

    — bd · 0 ba · — sqft

    11081 N Radio Station Road, Seneca, SC

    Dixie Meeks · Keller Williams Seneca

  22. 76.66 Acres Frontage Road and Knollwood Drive Road Keowee Interior — photoPrice Reduced16Active

    $3,833,000

    — bd · 0 ba · — sqft

    76.66 Acres Frontage Road and Knollwood Drive Road Keowee Interior, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  23. 45+/- Acres Knollwood Drive Keowee Interior — photo7Active

    $2,250,000

    — bd · 0 ba · — sqft

    45+/- Acres Knollwood Drive Keowee Interior, Seneca, SC

    Adrienne Hennes · RE/MAX Executive/Greenville

  24. 1.8 Acres Rochester Highway — photoPrice Reduced20Active

    $699,000

    — bd · 0 ba · — sqft

    1.8 Acres Rochester Highway, Seneca, SC

    PARKER STUART · ERA Kennedy Group

12
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Listing data & MLS disclosures

Greater Greenville Association of REALTORS
IDX information is provided exclusively for personal, non-commercial use, and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information is deemed reliable but not guaranteed.
Listing information ©2026 Greater Greenville Association of Realtors, Inc®. All Rights Reserved. Last Updated: 2026-06-12 19:30:43 UTC
Western Upstate Multiple Listing Service
IDX information is provided exclusively for personal, non-commercial use, and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Information is deemed reliable but not guaranteed.
Listing information ©2026 Western Upstate Association of Realtors, Inc®. All Rights Reserved. Last Updated: 2026-08-25 20:45:44 UTC

Seneca, SC community profile

Population
9,336
Median income
$54,836
Housing units
4,482
People per sq. mi.
68.4
Area
136.4 sq. mi.

Source: HJN community data