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Defiance, MO Homes for Sale | Realty.com
Realty.com
Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

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    Registered offenders on the map

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    3 bedsNew constructionWith a pool
    16 listings
    Sell

    Selling Options

    • What's my home worth?
    • Compare selling options
    • Get an instant cash offer
    • Buy before you sell

    Resources

    • How selling works
    • When should I sell?
    • Home selling tips
    • Pricing your home
    • What's worth fixing first
    • Find a seller's agent
    Home Loans
    Find an Agent

    Homes for Sale in Defiance, MO

    Homes for Sale in Defiance, MO

    Hide Map
    16 Listings
    Map

    Homes for Sale in Defiance, MO

    16 Listings

    Your local brokerage

    TO

    Thomas O'Leary

    Realty.com

    Lic. #2020001504

    Call Thomas
    1. 2 Patrick Lane — photo82Active

      $750,000

      4 bd · 4 ba · 4,044 sqft

      2 Patrick Lane, Defiance, MO

      Cheryl Lade · Coldwell Banker Realty - Gundaker

    2. 2275 Highway F — photo55Active

      $7,748,800

      5 bd · 4 ba · 2,815 sqft

      2275 Highway F, Defiance, MO

      Catherine Shaw-Connely · Tom Shaw, REALTORS

    3. 2275 Highway F Lot 1 — photo55Active

      $3,450,000

      5 bd · 4 ba · 2,815 sqft

      2275 Highway F Lot 1, Defiance, MO

      Catherine Shaw-Connely · Tom Shaw, REALTORS

    4. 19 Greenview Drive — photo45Active

      $624,900

      3 bd · 3 ba · 1,935 sqft

      19 Greenview Drive, Defiance, MO

      Michelle Syberg · Mid America Property Partners

    5. 3840 Rooster Ridge Lane — photoPrice Reduced83Active

      $699,900

      3 bd · 4 ba · 5,601 sqft

      3840 Rooster Ridge Lane, Defiance, MO

      Brandon McNamee · Mac Realty Group

    6. 50 Wilderness Lane — photoPrice Reduced57Active

      $670,000

      3 bd · 2 ba · 2,336 sqft

      50 Wilderness Lane, Defiance, MO

      Lisa Burkemper · Berkshire Hathaway HomeServices Select Properties

    7. 29 Greenview Drive — photo70Active

      $665,999

      4 bd · 4 ba · 4,025 sqft

      29 Greenview Drive, Defiance, MO

      Michael Nettemeyer · Nettwork Global

    8. 85 Mar Len Drive — photo74Active

      $650,000

      3 bd · 3 ba · 3,730 sqft

      85 Mar Len Drive, Defiance, MO

      Brittany Wasson · Christal Property Group, LLC

    9. 215 Rugged Acres — photoPrice Reduced19Active

      $639,000

      3 bd · 2 ba · 2,013 sqft

      215 Rugged Acres, Defiance, MO

      Stacey Manner · Call Dolly, LLC

    10. 8 Whippoorwill Court — photoPrice Reduced76Active

      $559,900

      4 bd · 4 ba · 3,057 sqft

      8 Whippoorwill Court, Defiance, MO

      Jennifer Bommarito · Fox & Riley Real Estate

    11. 44 Wilderness Lane — photoPrice Reduced58Active

      $610,000

      4 bd · 3 ba · 3,000 sqft

      44 Wilderness Lane, Defiance, MO

      Mike Simms · Worth Clark Realty

    12. 3901 Highway D — photoPrice Reduced32Active

      $364,950

      3 bd · 1 ba · 1,296 sqft

      3901 Highway D, Defiance, MO

      Michelle Syberg · Mid America Property Partners

    13. 220 Northlind Drive — photo79Active

      $1,400,000

      5 bd · 7 ba · 6,521 sqft

      220 Northlind Drive, Defiance, MO

      Mark & Neil Gellman · EXP Realty, LLC

    14. 3877 Highway D — photoPrice Reduced37Active

      $505,900

      3 bd · 2 ba · 1,600 sqft

      3877 Highway D, Defiance, MO

      Sherry Raleigh-Adams · Wolfe Realty

    15. 800 Matson Hill Road — photo53Active

      $649,900

      4 bd · 3 ba · 2,479 sqft

      800 Matson Hill Road, Defiance, MO

      Suzanne Matyiko · ReeceNichols Real Estate

    16. 51 Nordic Lane — photo97Active

      $695,000

      3 bd · 3 ba · 2,852 sqft

      51 Nordic Lane, Defiance, MO

      Mary Bay · Coldwell Banker Realty - Gundaker

    Explore Defiance homes

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    • Under $300K
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    • 2 beds
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    By type

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    L. Custen Realty, Inc. d/b/a Realty.com/L. Custen Realty CT, LLC d/b/a Realty.com (Tom O’Leary-Broker)(CT properties only), 8323 Southwest Freeway, Suite 900, Houston, Texas 77074

    Equal Housing OpportunityEqual Housing Lender

    The information provided by this website is for the personal, non-commercial use of consumers and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listing data is derived from various Multiple Listing Services; each source MLS and its required disclaimer are shown with the listings on the applicable page. Realty.com is an independently owned and operated brokerage.

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    Listing data & MLS disclosures

    MARIS MLS
    Based on information submitted to the MLS GRID as of 2026-09-14 19:37:51 UTC. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.
  • Co-ops
  • By feature

    • New construction
    • With a pool

    Your local brokerage

    TO

    Thomas O'Leary

    Realty.com

    Lic. #2020001504

    Call Thomas

    Defiance, MO community profile

    Area
    55 sq. mi.

    Source: HJN community data

    Defiance housing market

    August 2026 · This period is still settling

    Homes on the market · MLS, as of Aug 31, 2026

    Median list price
    $649,950
    Homes for sale
    14

    Housing stock — every home in the area, not only the ones selling or listed · Assessor records, as of Jul 29, 2026

    Median home size
    2,863 sq. ft.

    Nearby areas

    ZIP codes

    • 63385 (253)
    • 63368 (105)
    • 63376 (104)
    • 63301 (92)
    • 63367 (91)
    • 63366 (87)
    • 63017 (78)
    • 63021 (75)

    Cities

    • O'Fallon (221)
    • Wentzville (186)
    • St Charles (175)
    • St Peters (107)
    • Chesterfield (95)
    • Ballwin (93)
    • Lake St Louis (88)
    • St Louis (70)