Realty.com
Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

Make the deal

  • Writing a winning offer
  • Inspections & appraisals
  • Closing costs, itemized
  • Find a buyer's agent
Sell

Selling Options

  • What's my home worth?
  • Compare selling options
  • Get an instant cash offer
  • Buy before you sell

Resources

  • How selling works
  • When should I sell?
  • Home selling tips
  • Pricing your home
  • What's worth fixing first
  • Find a seller's agent
Home Loans
Find an Agent
Save searchAdvertiseSign In
Saved homesSaved searchesYour toursYour inquiriesRecently viewedAccount settings

Save search

Map layers

Safety

Safety & registry resources

Review official public-safety information for any area from these government sources:

  • U.S. Dept. of Justice National Sex Offender Public Website (NSOPW)
  • FBI: state sex-offender registry directory
Commercial Real Estate for Sale and Lease in Sikeston, MO | Realty.com
Realty.com
Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

Make the deal

  • Writing a winning offer
  • Inspections & appraisals
  • Closing costs, itemized
  • Find a buyer's agent
Save searchAdvertiseSign In
Saved homesSaved searchesYour toursYour inquiriesRecently viewedAccount settings
  • Residential
  • Rentals

30 listings
Sell

Selling Options

  • What's my home worth?
  • Compare selling options
  • Get an instant cash offer
  • Buy before you sell

Resources

  • How selling works
  • When should I sell?
  • Home selling tips
  • Pricing your home
  • What's worth fixing first
  • Find a seller's agent
Home Loans
Find an Agent
Save search

Commercial Real Estate for Sale and Lease in Sikeston, MO

Commercial Real Estate for Sale and Lease in Sikeston, MO

Hide Map
24 of 30 Listings
Map

Commercial Real Estate for Sale and Lease in Sikeston, MO

24 of 30 Listings

  1. 908 S Kingshighway Street — photo6Active

    $1,200,000

    0 bd · 0 ba · 24,984 sqft

    908 S Kingshighway Street, Sikeston, MO

    Rebecca Ault · EDGE Realty, ERA Powered

  2. 209 W Malone Avenue — photo31Active

    $700,000

    0 bd · 0 ba · 16,935 sqft

    209 W Malone Avenue, Sikeston, MO

    Brandon Sparks · SMG Realty

  3. 1103 S Main Street — photo6Active

    $1,200,000

    0 bd · 0 ba · 4,939 sqft

    1103 S Main Street, Sikeston, MO

    Reida Kimes · Century 21 Premiere Realty

  4. 526 S Frisco Street — photo13Active

    $250,000

    0 bd · 0 ba · 11,196 sqft

    526 S Frisco Street, Sikeston, MO

    Lawren McMullan · EDGE Realty, ERA Powered

  5. 951 S Kingshighway — photo61Active

    $1,600,000

    0 bd · 0 ba · 19,813 sqft

    951 S Kingshighway, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  6. 330 State Highway H — photo54Active

    $799,000

    0 bd · 0 ba · — sqft

    330 State Highway H, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  7. 900 S Main Street — photo8Active

    $4,800/mo

    0 bd · 0 ba · — sqft

    900 S Main Street, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  8. Tbd South Interstate Drive — photoPrice Reduced4Active

    $189,000

    0 bd · 0 ba · — sqft

    Tbd South Interstate Drive, Sikeston, MO

    LeAnn Adams · Silverthorn Realty

  9. 133 W Malone Avenue — photo2Active

    $299,000

    0 bd · 0 ba · — sqft

    133 W Malone Avenue, Sikeston, MO

    Terrence Beal · EXP Realty, LLC

  10. 20079 US Highway 61 — photoPrice Reduced10Active

    $140,000

    0 bd · 0 ba · 2,338 sqft

    20079 US Highway 61, Sikeston, MO

    Brandon Sparks · SMG Realty

  11. 205 S New Madrid Street — photoPrice Reduced73Active

    $399,000

    0 bd · 0 ba · 19,498 sqft

    205 S New Madrid Street, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  12. 1207 W Malone Avenue — photo18Active

    $699,900

    0 bd · 0 ba · 2,196 sqft

    1207 W Malone Avenue, Sikeston, MO

    LaDonna Dalton · Century 21 Ashland Realty

  13. 0 Highway 61 S — photo8Active

    $775,000

    0 bd · 0 ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  14. 0 Highway 61 S — photo7Active

    $975,000

    0 bd · 0 ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  15. 0 Highway 61 S — photo11Active

    $1,350,000

    0 bd · 0 ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  16. 328 S Interstate Drive — photoPrice Reduced21Active

    $3,999/mo

    0 bd · 0 ba · — sqft

    328 S Interstate Drive, Sikeston, MO

    Chris Cole · Lorimont L.C.

  17. 1102 S Main Street 1105 — photo1Active

    $2,214/mo

    0 bd · 0 ba · — sqft

    1102 S Main Street 1105, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  18. 1102 S Main Street 1103 — photo1Active

    $3,682/mo

    0 bd · 0 ba · — sqft

    1102 S Main Street 1103, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  19. 600 N Main Street E — photo3Active

    $1,950/mo

    0 bd · 0 ba · — sqft

    600 N Main Street E, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  20. 210 S Kingshighway Street — photo6Active

    $775,000

    0 bd · 0 ba · — sqft

    210 S Kingshighway Street, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  21. 112 Front Street — photoPrice Reduced36Active

    $190,000

    0 bd · 0 ba · 6,321 sqft

    112 Front Street, Sikeston, MO

    Sandy Tegel · Century 21 Ashland Realty

  22. 300 Matthews Lane — photo12Active

    $1,100,000

    0 bd · 0 ba · 24,700 sqft

    300 Matthews Lane, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  23. 2008 & 2010 N Main Street — photoPrice Reduced37Active

    $499,000

    0 bd · 0 ba · — sqft

    2008 & 2010 N Main Street, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  24. 300 Matthews Lane Front — photo1Active

    $5,000/mo

    0 bd · 0 ba · 20,000 sqft

    300 Matthews Lane Front, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

12
Realty.com

L. Custen Realty, Inc. d/b/a Realty.com/L. Custen Realty CT, LLC d/b/a Realty.com (Tom O’Leary-Broker)(CT properties only), 8323 Southwest Freeway, Suite 900, Houston, Texas 77074

Equal Housing OpportunityEqual Housing Lender

The information provided by this website is for the personal, non-commercial use of consumers and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listing data is derived from various Multiple Listing Services; each source MLS and its required disclaimer are shown with the listings on the applicable page. Realty.com is an independently owned and operated brokerage.

© 2026 Realty.com. All rights reserved.·Privacy·Terms·California Privacy Rights·Accessibility·Licensing

Listing data & MLS disclosures

MARIS MLS
Based on information submitted to the MLS GRID as of 2026-10-15 16:01:42 UTC. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

Sikeston, MO community profile

Population
16,198
Median income
$49,472
Housing units
7,287
People per sq. mi.
73.1
Area
221.7 sq. mi.

Source: HJN community data