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Commercial Real Estate for Sale and Lease in Sikeston, MO | Realty.com
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25 listings
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Commercial Real Estate for Sale and Lease in Sikeston, MO

Commercial Real Estate for Sale and Lease in Sikeston, MO

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24 of 25 Listings
Map

Commercial Real Estate for Sale and Lease in Sikeston, MO

24 of 25 Listings

  1. 330 State Highway H — photo54Active

    $799,000

    — bd · — ba · — sqft

    330 State Highway H, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  2. 900 S Main Street — photo5Active

    $4,800/mo

    — bd · — ba · — sqft

    900 S Main Street, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  3. Tbd South Interstate Dr — photo4Active

    $199,000

    — bd · — ba · — sqft

    Tbd South Interstate Dr, Sikeston, MO

    LeAnn Adams · Silverthorn Realty

  4. 133 W Malone Avenue — photo2Active

    $299,000

    — bd · — ba · — sqft

    133 W Malone Avenue, Sikeston, MO

    Terrence Beal · EXP Realty, LLC

  5. 20079 US Highway 61 — photo10Active

    $165,000

    — bd · — ba · — sqft

    20079 US Highway 61, Sikeston, MO

    Brandon Sparks · SMG Realty

  6. 205 S New Madrid Street — photo73Active

    $449,500

    — bd · — ba · — sqft

    205 S New Madrid Street, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  7. 1207 W Malone Avenue — photo18Active

    $699,900

    — bd · — ba · — sqft

    1207 W Malone Avenue, Sikeston, MO

    LaDonna Dalton · Century 21 Ashland Realty

  8. 0 Highway 61 S — photo8Active

    $1,350,000

    — bd · — ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  9. 0 Highway 61 S — photo3Active

    $975,000

    — bd · — ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  10. 0 Highway 61 S — photo3Active

    $775,000

    — bd · — ba · — sqft

    0 Highway 61 S, Sikeston, MO

    Matthew Huber · Lorimont L.C.

  11. 328 S Interstate Drive — photoPrice Reduced21Active

    $3,999/mo

    — bd · — ba · — sqft

    328 S Interstate Drive, Sikeston, MO

    Chris Cole · Lorimont L.C.

  12. 1102 S Main Street 1105 — photo1Active

    $2,214/mo

    — bd · — ba · — sqft

    1102 S Main Street 1105, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  13. 1102 S Main Street 1103 — photo1Active

    $3,682/mo

    — bd · — ba · — sqft

    1102 S Main Street 1103, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  14. 600 N Main Street E — photo3Active

    $1,950/mo

    — bd · — ba · — sqft

    600 N Main Street E, Sikeston, MO

    Tom Kelsey · Lorimont L.C.

  15. 210 S Kingshighway Street — photo6Active

    $775,000

    — bd · — ba · — sqft

    210 S Kingshighway Street, Sikeston, MO

    Larry Lindsey · Century 21 Premiere Realty

  16. 112 Front Street — photoPrice Reduced36Active

    $190,000

    — bd · — ba · — sqft

    112 Front Street, Sikeston, MO

    Sandy Tegel · Century 21 Ashland Realty

  17. 300 Matthews Lane — photo12Active

    $1,100,000

    — bd · — ba · — sqft

    300 Matthews Lane, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  18. 2008 & 2010 N Main Street — photoPrice Reduced37Active

    $549,000

    — bd · — ba · — sqft

    2008 & 2010 N Main Street, Sikeston, MO

    Jacob Fish · EDGE Realty ERA Powered

  19. 300 Matthews Lane Front — photo1Active

    $5,000/mo

    — bd · — ba · — sqft

    300 Matthews Lane Front, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  20. 912 S Main Street — photo9Active

    $3,625/mo

    — bd · — ba · — sqft

    912 S Main Street, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  21. 202 S Kingshighway Street — photoPrice Reduced24Active

    $279,000

    — bd · — ba · — sqft

    202 S Kingshighway Street, Sikeston, MO

    Reida Kimes · Century 21 Premiere Realty

  22. 202 S Kingshighway Street — photo24Active

    $4,500/mo

    — bd · — ba · — sqft

    202 S Kingshighway Street, Sikeston, MO

    Reida Kimes · Century 21 Premiere Realty

  23. 124 E Front Street — photoPrice Reduced15Active

    $275,000

    — bd · — ba · 14,642 sqft

    124 E Front Street, Sikeston, MO

    Tim Merideth · Century 21 Premiere Realty

  24. 229 Westgate Street — photoPrice Reduced13Active

    $525,000

    — bd · — ba · 22,594 sqft

    229 Westgate Street, Sikeston, MO

    Ron Senciboy · Rose Real Estate

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Listing data & MLS disclosures

MARIS MLS
Based on information submitted to the MLS GRID as of 2026-08-27 03:43:35 UTC. All data is obtained from various sources and may not have been verified by broker or MLS GRID. Supplied Open House Information is subject to change without notice. All information should be independently reviewed and verified for accuracy. Properties may or may not be listed by the office/agent presenting the information.

Sikeston, MO community profile

Population
16,198
Median income
$49,472
Housing units
7,287
People per sq. mi.
73.1
Area
221.7 sq. mi.

Source: HJN community data