Realty.com
Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

Make the deal

  • Writing a winning offer
  • Inspections & appraisals
  • Closing costs, itemized
  • Find a buyer's agent
Sell

Selling Options

  • What's my home worth?
  • Compare selling options
  • Get an instant cash offer
  • Buy before you sell

Resources

  • How selling works
  • When should I sell?
  • Home selling tips
  • Pricing your home
  • What's worth fixing first
  • Find a seller's agent
Home Loans
Find an Agent
Save searchAdvertiseSign In
Saved homesSaved searchesYour toursYour inquiriesRecently viewedAccount settings

Save search

Map layers

Safety

Safety & registry resources

Review official public-safety information for any area from these government sources:

  • U.S. Dept. of Justice National Sex Offender Public Website (NSOPW)
  • FBI: state sex-offender registry directory
Commercial Real Estate for Sale and Lease in Clarksdale, MS | Realty.com
Realty.com
Buy

Start here

  • Homes for sale by state
  • Home buying tips
  • Before you start looking
  • The buying timeline

Afford it

  • Today's mortgage rates
  • Mortgage calculator
  • How much can I afford?
  • Get pre-approved

Make the deal

  • Writing a winning offer
  • Inspections & appraisals
  • Closing costs, itemized
  • Find a buyer's agent
Save searchAdvertiseSign In
Saved homesSaved searchesYour toursYour inquiriesRecently viewedAccount settings
  • Residential
  • Rentals

15 listings
Sell

Selling Options

  • What's my home worth?
  • Compare selling options
  • Get an instant cash offer
  • Buy before you sell

Resources

  • How selling works
  • When should I sell?
  • Home selling tips
  • Pricing your home
  • What's worth fixing first
  • Find a seller's agent
Home Loans
Find an Agent
Save search

Commercial Real Estate for Sale and Lease in Clarksdale, MS

Commercial Real Estate for Sale and Lease in Clarksdale, MS

Hide Map
15 Listings
Map

Commercial Real Estate for Sale and Lease in Clarksdale, MS

15 Listings

  1. 626 N State Street — photo10Active

    $460,000

    — bd · 0 ba · 3,800 sqft

    626 N State Street, Clarksdale, MS

    Valerie B Johnson · Integrity Real Estate Services

  2. 115 Court Street — photo1Active

    $361,200

    5 bd · 2 ba · 2,991 sqft

    115 Court Street, Clarksdale, MS

    Valerie B Johnson · Integrity Real Estate Services

  3. 617 N State Street — photo1Active

    $200,000

    — bd · 0 ba · 13,504 sqft

    617 N State Street, Clarksdale, MS

    Katheryn K Coleman · Powers Properties

  4. 1041 Desoto Avenue — photo22Active

    $1,300,000

    — bd · 0 ba · 10,400 sqft

    1041 Desoto Avenue, Clarksdale, MS

    Darrell W Bullock · Mossy Oak Properties Bottomlan

  5. 138 Sunflower Avenue — photoPrice Reduced15Active

    $159,000

    4 bd · 4 ba · 5,080 sqft

    138 Sunflower Avenue, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  6. 247 Delta Avenue — photo4Active

    $149,000

    — bd · 1 ba · 2,151 sqft

    247 Delta Avenue, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  7. 243 Delta Avenue — photo5Active

    $110,000

    — bd · 1 ba · 2,151 sqft

    243 Delta Avenue, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  8. 701 S State Street — photoPrice Reduced20Active

    $425,000

    — bd · 1 ba · 34,903 sqft

    701 S State Street, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  9. 250 Delta Avenue — photo7Active

    $185,000

    — bd · 0 ba · 5,371 sqft

    250 Delta Avenue, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  10. 271 Delta Avenue — photoPrice Reduced38Active

    $250,000

    4 bd · 5 ba · 3,848 sqft

    271 Delta Avenue, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  11. 143 Yazoo Avenue — photo1Active

    $155,000

    — bd · 0 ba · 2,900 sqft

    143 Yazoo Avenue, Clarksdale, MS

    Deborah D Luster · Hal Fiser Agency

  12. 104 E 2nd Street — photoPrice Reduced30Active

    $305,000

    4 bd · 5 ba · 10,350 sqft

    104 E 2nd Street, Clarksdale, MS

    Jones Luster · Mossy Oak Properties Bottomlan

  13. 417 Desoto Avenue — photo9Active

    $359,000

    — bd · 0 ba · 5,000 sqft

    417 Desoto Avenue, Clarksdale, MS

    Anthony Steen · Tom Smith Land & Homes

  14. 855 S State Street — photo13Active

    $499,000

    — bd · 0 ba · 10,000 sqft

    855 S State Street, Clarksdale, MS

    Anthony Steen · Tom Smith Land & Homes

  15. 529 N State Street — photo4Active

    $1,800/mo

    — bd · 0 ba · 1,000 sqft

    529 N State Street, Clarksdale, MS

    Anthony Steen · Tom Smith Land & Homes

Realty.com

L. Custen Realty, Inc. d/b/a Realty.com/L. Custen Realty CT, LLC d/b/a Realty.com (Tom O’Leary-Broker)(CT properties only), 8323 Southwest Freeway, Suite 900, Houston, Texas 77074

Equal Housing OpportunityEqual Housing Lender

The information provided by this website is for the personal, non-commercial use of consumers and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Listing data is derived from various Multiple Listing Services; each source MLS and its required disclaimer are shown with the listings on the applicable page. Realty.com is an independently owned and operated brokerage.

© 2026 Realty.com. All rights reserved.·Privacy·Terms·California Privacy Rights·Accessibility·Licensing

Listing data & MLS disclosures

MLS United
Information is deemed to be reliable but not guaranteed. Copyright © 2026 MLS United, LLC.

Clarksdale, MS community profile

Population
13,867
Median income
$38,822
Housing units
5,791
People per sq. mi.
49.5
Area
280 sq. mi.

Source: HJN community data