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Murphysboro is located in Illinois. Murphysboro, Illinois has a population of 7,523. Murphysboro is more family-centric than the surrounding county with 23% of the households containing married families with children. The county average for households married with children is 20%.

The median household income in Murphysboro, IL is $34,209. The median household income for the surrounding county is $36,218 compared to the national median of $57,525. The median age of people living in Murphysboro is 38 years old.

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